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Article

TERT promoter mutations and rs2853669 polymorphism: prognostic impact and interactions with common alterations in glioblastomas.

Journal of neuro-oncology - 1 Feb 2016

Nencha Umberto, Rahimian Amithys, Giry Marine, Sechi Andrea, Mokhtari Karima, Polivka Marc, Schmitt Yohann, Di Stefano Anna-Luisa, Alentorn Agusti, Labussière Marianne, Sanson Marc

Abstract excerpt

TERT promoter (TERTp) mutation is the most common mutation in glioblastomas. It creates a putative binding site for Ets/TCF transcription factors, enhancing telomerase expression and activity, whereas the rs2853669 variant disrupts another Ets/TCF binding. We explore here the interaction between these two alterations, tumor genomic profile and the impact on prognosis. The TERTp and rs2853669 statuses were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26608520
DOI: 10.1007/s11060-015-1999-3

Genes

EGFR
TERT
MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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