Article
The prognostic impact of TERT promoter mutations in glioblastomas is modified by the rs2853669 single nucleotide polymorphism.
International journal of cancer - 15 Jul 2016
Batista Rui, Cruvinel-Carloni Adriana, Vinagre João, Peixoto Joana, Catarino Telmo A, Campanella Nathalia Cristina, Menezes Weder, Becker Aline Paixão, de Almeida Gisele Caravina, Matsushita Marcus M, Clara Carlos, Neder Luciano, Viana-Pereira Marta, Honavar Mrinalini, Castro Lígia, Lopes José Manuel, Carvalho Bruno, Vaz Rui Manuel, Máximo Valdemar, Soares Paula, Sobrinho-Simões Manuel, Reis Rui Manuel, Lima Jorge
Abstract excerpt
Human hotspot TERT promoter (TERTp) mutations have been reported in a wide range of tumours. Several studies have shown that TERTp mutations are associated with clinicopathological features; in some instances, TERTp mutations were considered as biomarkers of poor prognosis. The rs2853669 SNP, located in the TERT promoter region, was reported to modulate the increased TERT expression levels induced by the...
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