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Article

Schizophrenia in translation: disrupted in schizophrenia (DISC1): integrating clinical and basic findings.

Schizophrenia bulletin - 1 Jan 2007

Roberts Rosalinda C

Abstract excerpt

The disrupted in schizophrenia 1 (DISC1) gene has been linked to schizophrenia and other serious mental illnesses in multiple pedigrees. This article will review the neurobiology of DISC1 in normal developing and adult brain and the putative role of the mutant form in major mental illness, particularly schizophrenia. The initial genetic finding of an association between DISC1 and schizophrenia in a Scottish...

Topics

Animals
Brain
DNA Mutational Analysis
Disease Models, Animal
Genetic Predisposition to Disease
Humans
Mice, Neurologic Mutants
Nerve Tissue Proteins
Neuronal Plasticity
Neurons
Schizophrenia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Synaptic Transmission

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Open in PubMed Open full text

Identifiers

PMID: 17138582
DOI: 10.1093/schbul/sbl063
PMCID: PMC2632285

Genes

DISC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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