Article
Linking neurodevelopmental and synaptic theories of mental illness through DISC1.
Nature reviews. Neuroscience - 18 Nov 2011
Brandon Nicholas J, Sawa Akira
Abstract excerpt
Recent advances in our understanding of the underlying genetic architecture of psychiatric disorders has blown away the diagnostic boundaries that are defined by currently used diagnostic manuals. The disrupted in schizophrenia 1 (DISC1) gene was originally discovered at the breakpoint of an inherited chromosomal translocation, which segregates with major mental illnesses. In addition, many biological studies...
Topics
- Animals
- Brain
- Gene Expression Regulation, Developmental
- Genetic Predisposition to Disease
- Humans
- Mental Disorders
- Models, Biological
- Nerve Tissue Proteins
- Synapses
- Translocation, Genetic