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Article

Mutant disrupted-in-schizophrenia 1 in astrocytes: focus on glutamate metabolism.

Journal of neuroscience research - 1 Dec 2014

Abazyan Sofya, Yang Eun Ju, Abazyan Bagrat, Xia Meng, Yang Chunxia, Rojas Camilo, Slusher Barbara, Sattler Rita, Pletnikov Mikhail

Abstract excerpt

Disrupted-in-schizophrenia 1 (DISC1) is a genetic risk factor that has been implicated in major mental disorders. DISC1 binds to and stabilizes serine racemase to regulate production of D-serine by astrocytes, contributing to glutamate (GLU) neurotransmission. However, the possible involvement of astrocytic DISC1 in synthesis, metabolism, reuptake, or secretion of GLU remains unexplored. Therefore, we studied the...

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Identifiers

PMID: 25131692
DOI: 10.1002/jnr.23459
PMCID: PMC4247786

Genes

DISC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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