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Dysregulation of Multiple Solute Carrier genes and Metabolic Deficits in <i>SLC1A4</i> -Mutant Human iPSC-Derived Hippocampal Neurons

2025-04-29

Abstract excerpt

Mutations in SLC1A4 , which encodes the neuronal amino acid transporter ASCT1, disrupt metabolic and synaptic homeostasis, contributing to neurodevelopmental deficits commonly observed in autism spectrum disorder (ASD). To investigate the underlying molecular mechanisms of SLC1A4 -related disorders, we utilized human iPSC-derived hippocampal neurons and applied an integrated multi-omics approach, combining elect...

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Literature Corpus work
2e54646d-4ddb-54f0-8808-fd3439f757db
DOI
10.1101/2025.04.25.650669
Open publication

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