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Article

The alanine-serine-cysteine-1 (Asc-1) transporter controls glycine levels in the brain and is required for glycinergic inhibitory transmission.

EMBO reports - 1 May 2015

Safory Hazem, Neame Samah, Shulman Yoav, Zubedat Salman, Radzishevsky Inna, Rosenberg Dina, Sason Hagit, Engelender Simone, Avital Avi, Hülsmann Swen, Schiller Jackie, Wolosker Herman

Abstract excerpt

Asc-1 (SLC7A10) is an amino acid transporter whose deletion causes neurological abnormalities and early postnatal death in mice. Using metabolomics and behavioral and electrophysiological methods, we demonstrate that Asc-1 knockout mice display a marked decrease in glycine levels in the brain and spinal cord along with impairment of glycinergic inhibitory transmission, and a hyperekplexia-like phenotype that is...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 25755256
DOI: 10.15252/embr.201439561
PMCID: PMC4428048

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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