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Article

Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model.

Human molecular genetics - 1 Sept 2009

Labrie Viviane, Fukumura Ryutaro, Rastogi Anjali, Fick Laura J, Wang Wei, Boutros Paul C, Kennedy James L, Semeralul Mawahib O, Lee Frankie H, Baker Glen B, Belsham Denise D, Barger Steven W, Gondo Yoichi, Wong Albert H C, Roder John C

Abstract excerpt

Abnormal N-methyl-d-aspartate receptor (NMDAR) function has been implicated in the pathophysiology of schizophrenia. d-serine is an important NMDAR modulator, and to elucidate the role of the d-serine synthesis enzyme serine racemase (Srr) in schizophrenia, we identified and characterized mice with an ENU-induced mutation that results in a complete loss of Srr activity and dramatically reduced d-serine levels....

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Identifiers

PMID: 19483194
DOI: 10.1093/hmg/ddp261
PMCID: PMC2722985

Genes

SRR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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