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Article

Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion.

Molecular psychiatry - 1 May 2013

Ma T M, Abazyan S, Abazyan B, Nomura J, Yang C, Seshadri S, Sawa A, Snyder S H, Pletnikov M V

Abstract excerpt

Perturbation of Disrupted-In-Schizophrenia-1 (DISC1) and D-serine/NMDA receptor hypofunction have both been implicated in the pathophysiology of schizophrenia and other psychiatric disorders. In the present study, we demonstrate that these two pathways intersect with behavioral consequences. DISC1 binds to and stabilizes serine racemase (SR), the enzyme that generates D-serine, an endogenous co-agonist of the...

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Source

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Identifiers

PMID: 22801410
DOI: 10.1038/mp.2012.97
PMCID: PMC3475769

Genes

DISC1
PICK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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