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Article

Telomerase activation after recruitment in fission yeast.

Current biology : CB - 8 Sept 2014

Armstrong Christine Anne, Pearson Siân Rosanna, Amelina Hanna, Moiseeva Vera, Tomita Kazunori

Abstract excerpt

Current models depict that telomerase recruitment equates to activation. Telomeric DNA-binding proteins and the telomerase accessory proteins coordinate the recruitment of telomerase to the ends of chromosomes in a telomere length- and cell-cycle-dependent manner [1-4]. Recent studies have demonstrated that the telomeric protein TPP1 and its binding protein TIN2 are key proteins for both telomerase recruitment...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Schizosaccharomyces

Share to Schizosaccharomyces pombe Proteins

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Source

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Identifiers

PMID: 25131669
DOI: 10.1016/j.cub.2014.07.035
PMCID: PMC4159562

Genes

TPP1
POT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Telomerase activation after recruitment in fission yeast.PMID 25131669Read ↗

Fission yeast Ccq1 is a modulator of telomerase activity.Semantic proximity Read ↗

Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length.Semantic proximity Read ↗

TIN2-Tethered TPP1 Recruits Human Telomerase to Telomeres In VivoSemantic proximity Read ↗

Tpz1 controls a telomerase-nonextendible telomeric state and coordinates switching to an extendible state via Ccq1.Semantic proximity Read ↗

Structural basis of human telomerase recruitment by TPP1-POT1Semantic proximity Read ↗

The structurally conserved TELR region on shelterin protein TPP1 is essential for telomerase processivity but not recruitmentSemantic proximity Read ↗

CTC1 OB-B interaction with TPP1 terminates telomerase and prevents telomere overextension.Semantic proximity Read ↗

Multi-step coordination of telomerase recruitment in fission yeast through two coupled telomere-telomerase interfaces.Semantic proximity Read ↗

Arabidopsis POT1 associates with the telomerase RNP and is required for telomere maintenance.Semantic proximity Read ↗

Pot1 inactivation leads to rampant telomere resection and loss in one cell cycle.Semantic proximity Read ↗

A yeast telomerase complex containing the Est1 recruitment protein is assembled early in the cell cycle.Semantic proximity Read ↗

PTOP interacts with POT1 and regulates its localization to telomeres.Semantic proximity Read ↗

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