Article
CTC1 OB-B interaction with TPP1 terminates telomerase and prevents telomere overextension.
Nucleic acids research - 9 Jun 2023
Wang Huan, Ma Tengfei, Zhang Xiaotong, Chen Wei, Lan Yina, Kuang Guotao, Hsu Shih-Jui, He Zibin, Chen Yuxi, Stewart Jason, Bhattacharjee Anukana, Luo Zhenhua, Price Carolyn, Feng Xuyang
Abstract excerpt
CST (CTC1-STN1-TEN1) is a telomere associated complex that binds ssDNA and is required for multiple steps in telomere replication, including termination of G-strand extension by telomerase and synthesis of the complementary C-strand. CST contains seven OB-folds which appear to mediate CST function by modulating CST binding to ssDNA and the ability of CST to recruit or engage partner proteins. However, the...
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