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Article

TIN2-Tethered TPP1 Recruits Human Telomerase to Telomeres In Vivo

19 Apr 2010

Abstract excerpt

Recruitment to telomeres is a pivotal step in the function and regulation of human telomerase; however, the molecular basis for recruitment is not known. Here, we have directly investigated the process of telomerase recruitment via fluorescence in situ hybridization (FISH) and chromatin immunoprecipitation (ChIP). We find that depletion of two components of the shelterin complex that is found at telomeres--TPP1...

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Share to Advanced biosensing and bioanalysis techniques
Share to DNA Repair Mechanisms
Share to Telomeres, Telomerase, and Senescence

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PMID: 20404094
DOI: 10.1128/mcb.00240-10

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TIN2-Tethered TPP1 Recruits Human Telomerase to Telomeres In VivoPMID 20404094Read ↗

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Structural basis of human telomerase recruitment by TPP1-POT1Semantic proximity Read ↗

In Vivo Stoichiometry of Shelterin ComponentsSemantic proximity Read ↗

POT1 Association with TRF2 Regulates Telomere LengthSemantic proximity Read ↗

TIN2 Functions with TPP1/POT1 To Stimulate Telomerase ProcessivitySemantic proximity Read ↗

PTOP interacts with POT1 and regulates its localization to telomeres.Semantic proximity Read ↗

Human shelterin protein POT1 prevents severe telomere instability induced by homology-directed DNA repair.Semantic proximity Read ↗

Characterization of the DNA binding specificity of Shelterin complexesSemantic proximity Read ↗

POT1-TPP1 telomere length regulation and diseaseSemantic proximity Read ↗

Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivitySemantic proximity Read ↗

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