Article
A yeast telomerase complex containing the Est1 recruitment protein is assembled early in the cell cycle.
Biochemistry - 19 Feb 2013
Tucey Timothy M, Lundblad Victoria
Abstract excerpt
In budding yeast, association of the Est1 regulatory protein with telomerase is thought to be limited to the late S phase, when telomere elongation occurs. By monitoring the stoichiometry of telomerase subunits, we show instead that a telomerase complex containing Est1 is assembled much earlier in the cell cycle. We also report a biochemical interaction between Est1 and the telomere binding protein Cdc13 that...
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