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Article

Pot1 inactivation leads to rampant telomere resection and loss in one cell cycle.

Nucleic acids research - 1 Nov 2010

Pitt Christopher W, Cooper Julia Promisel

Abstract excerpt

Removal of the conserved telomere protein, Pot1, confers the immediate loss of fission yeast telomeres. This drastic phenotype has established the centrality of Pot1 for telomere maintenance but prohibited elucidation of the intermediate steps leading to telomere loss. To circumvent this problem,...

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Identifiers

PMID: 20601686
DOI: 10.1093/nar/gkq580
PMCID: PMC2978358

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20601686-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Pot1 inactivation leads to rampant telomere resection and loss in one cell cycle.PMID 20601686Read ↗

Distinct requirements for Pot1 in limiting telomere length and maintaining chromosome stability.Semantic proximity Read ↗

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Replication stress conferred by POT1 dysfunction promotes telomere relocalization to the nuclear pore.Semantic proximity Read ↗

Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length.Semantic proximity Read ↗

Distinct functions of POT1 at telomeres.Semantic proximity Read ↗

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Mutation in fission yeast phosphatidylinositol 4-kinase Pik1 is synthetically lethal with defect in telomere protection protein Pot1.Semantic proximity Read ↗

POT1 mutations cause differential effects on telomere length leading to opposing disease phenotypes.Semantic proximity Read ↗

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