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Article

Biochemical analysis of the canonical model for the mammalian circadian clock.

The Journal of biological chemistry - 22 Jul 2011

Ye Rui, Selby Christopher P, Ozturk Nuri, Annayev Yunus, Sancar Aziz

Abstract excerpt

The current consensus model for the circadian clock in mammals is based on a transcription-translation feedback loop. In this model, CRY and PER proteins repress their own transcription by suppressing the transactivator function of the CLOCK:BMAL1 heterodimer directly (physical model) and by facilitating post-translational modifications (chemical model). Most of the data for this model come from genetic and cell...

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Source

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Identifiers

PMID: 21613214
DOI: 10.1074/jbc.M111.254680
PMCID: PMC3138243

Genes

BMAL1
CLOCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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