Article
Linear motifs in the C-terminus of D. melanogaster cryptochrome.
Biochemical and biophysical research communications - 6 Apr 2007
Hemsley Matthew J, Mazzotta Gabriella M, Mason Moyra, Dissel Stephane, Toppo Stefano, Pagano Mario A, Sandrelli Federica, Meggio Flavio, Rosato Ezio, Costa Rodolfo, Tosatto Silvio C E
Abstract excerpt
The C-terminus of cryptochrome (CRY) regulates light responses in Drosophila. These include the light-dependent binding of Drosophila dCRY to the clock proteins PERIOD and TIMELESS in a yeast two-hybrid system, which we proved to be a convenient and reliable readout of the behavior of dCRY in vivo. In this study, we present a combination of in silico analysis and experimental validation in yeast, to identify...
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