Article
Roles of the two Drosophila CRYPTOCHROME structural domains in circadian photoreception.
Science (New York, N.Y.) - 4 Jun 2004
Busza Ania, Emery-Le Myai, Rosbash Michael, Emery Patrick
Abstract excerpt
CRYPTOCHROME (CRY) is the primary circadian photoreceptor in Drosophila. We show that CRY binding to TIMELESS (TIM) is light-dependent in flies and irreversibly commits TIM to proteasomal degradation. In contrast, CRY degradation is dependent on continuous light exposure, indicating that the CRY-TIM interaction is transient. A novel cry mutation (cry(m)) reveals that CRY's photolyase homology domain is sufficient...
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