Article
Interacting molecular loops in the mammalian circadian clock.
Science (New York, N.Y.) - 12 May 2000
Shearman L P, Sriram S, Weaver D R, Maywood E S, Chaves I, Zheng B, Kume K, Lee C C, van der Horst G T, Hastings M H, Reppert S M
Abstract excerpt
We show that, in the mouse, the core mechanism for the master circadian clock consists of interacting positive and negative transcription and translation feedback loops. Analysis of Clock/Clock mutant mice, homozygous Period2(Brdm1) mutants, and Cryptochrome-deficient mice reveals substantially altered Bmal1 rhythms, consistent with a dominant role of PERIOD2 in the positive regulation of the Bmal1 loop. In vitro...
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