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Article

Transcriptional and epigenetic regulation of T-helper lineage specification.

Immunological reviews - 1 Sept 2014

Tripathi Subhash K, Lahesmaa Riitta

Abstract excerpt

Combined with TCR stimuli, extracellular cytokine signals initiate the differentiation of naive CD4(+) T cells into specialized effector T-helper (Th) and regulatory T (Treg) cell subsets. The lineage specification and commitment process occurs through the combinatorial action of multiple transcription factors (TFs) and epigenetic mechanisms that drive lineage-specific gene expression programs. In this article,...

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Share to Cell Differentiation
Share to Cell Lineage
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Immune System Diseases

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Share to T-Lymphocytes, Helper-Inducer

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Source

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Identifiers

PMID: 25123277
DOI: 10.1111/imr.12204
PMCID: PMC4255756

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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