Critical Link Between Epigenetics and Transcription Factors in the Induction of Autoimmunity: a Comprehensive Review.

doi:10.1007/s12016-016-8534-y

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Article

Critical Link Between Epigenetics and Transcription Factors in the Induction of Autoimmunity: a Comprehensive Review.

Clinical reviews in allergy & immunology - 1 Jun 2016

Wu Haijing, Zhao Ming, Yoshimura Akihiko, Chang Christopher, Lu Qianjin

Abstract excerpt

Autoimmune diseases occur when the immune system loses tolerance to self-antigens, inducing inflammation and tissue damage. The pathogenesis of autoimmune diseases has not been elucidated. A growing mountain of evidence suggests the involvement of genetic and epigenetic factors in the development of these disorders. Genetic mapping has identified several candidate variants in autoimmune conditions. However,...

Topics

Animals
Autoimmune Diseases
Autoimmunity
Carrier Proteins
CpG Islands
DNA (Cytosine-5-)-Methyltransferases
DNA Methylation
Epigenesis, Genetic
Gene Expression Regulation
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Histones

Humans

MicroRNAs

Protein Binding

RNA, Long Noncoding

Transcription Factors

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Open in PubMed

Identifiers

PMID: 26969025
DOI: 10.1007/s12016-016-8534-y

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