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Transcriptional Regulation of Early T-Lymphocyte Development in Thymus

31 Mar 2022

Abstract excerpt

T-lymphocytes play crucial roles for maintaining immune homeostasis by fighting against various pathogenic microorganisms and establishing self-antigen tolerance. They will go through several stages and checkpoints in the thymus from progenitors to mature T cells, from CD4 - CD8 - double negative (DN) cells to CD4 + CD8 + double positive (DP) cells, finally become CD4 + or CD8 + single positive (SP) cells. The...

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PMID: 35432347
DOI: 10.3389/fimmu.2022.884569

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