Article
Epigenetic changes in inflammatory and autoimmune diseases.
Sub-cellular biochemistry - 1 Jan 2013
Nielsen Helene Myrtue, Tost Jörg
Abstract excerpt
In higher eukaryotic organisms epigenetic modifications are crucial for proper chromatin folding and thereby proper regulation of gene expression. In the last years the involvement of aberrant epigenetic modifications in inflammatory and autoimmune diseases has been recognized and attracted significant interest. However, the epigenetic mechanisms underlying the different disease phenotypes are still poorly...
Topics
- Animals
- Autoimmune Diseases
- Autoimmunity
- Cell Differentiation
- Chromatin
- Chromatin Assembly and Disassembly
- Cytokines
- Epigenesis, Genetic
- Gene Expression Regulation
- Genetic Predisposition to Disease
- Humans
