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Identification of global regulators of T-helper cell lineage specification

20 Nov 2015

Abstract excerpt

BACKGROUND: Activation and differentiation of T-helper (Th) cells into Th1 and Th2 types is a complex process orchestrated by distinct gene activation programs engaging a number of genes. This process is crucial for a robust immune response and an imbalance might lead to disease states such as autoimmune diseases or allergy. Therefore, identification of genes involved in this process is paramount to further...

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PMID: 26589177
DOI: 10.1186/s13073-015-0237-0

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