Article
Robust quantitative assessments of cytosine modifications and changes in the expressions of related enzymes in gastric cancer.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association - 1 Jul 2015
Du Chunping, Kurabe Nobuya, Matsushima Yoshitaka, Suzuki Masako, Kahyo Tomoaki, Ohnishi Ippei, Tanioka Fumihiko, Tajima Shogo, Goto Masanori, Yamada Hidetaka, Tao Hong, Shinmura Kazuya, Konno Hiroyuki, Sugimura Haruhiko
Abstract excerpt
BACKGROUND: The rediscovery of 5-hydroxymethylcytosine, the ten-eleven translocation (TET) family, thymine-DNA glycosylase (TDG) and isocitrate dehydrogenase (IDH) have opened new avenues in the study of DNA demethylation pathways in gastric cancer (GC). We performed a comprehensive and robust analysis of these genes and modified cytosines in gastric cancer. METHODS: Liquid chromatography mass spectrometry/mass...
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