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Article

IDH1/2 Mutants Inhibit TET-Promoted Oxidation of RNA 5mC to 5hmC.

PloS one - 1 Jan 2016

Xu Qiang, Wang Kai, Wang Lina, Zhu Yuting, Zhou Guangyu, Xie Dan, Yang Qingkai

Abstract excerpt

TETs (TET1/2/3) play critical roles in multi cellular processes through DNA demethylation driven by oxidation of DNA 5mdC to 5hmdC. Interestingly, recent studies indicated that TETs also oxidate RNA 5mC to 5hmC. However, little is known about the distribution of RNA 5hmC and the regulatory mechanism of RNA 5hmC in human. Here, we show that 5hmC is enriched in mRNA, and IDH1/2 mutants inhibit TET-promoted...

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Source

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Identifiers

PMID: 27548812
DOI: 10.1371/journal.pone.0161261
PMCID: PMC4993491

Genes

IDH1
TET1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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