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Article

Loss of 5-hydroxymethylcytosine is accompanied with malignant cellular transformation.

Cancer science - 1 Apr 2012

Kudo Yotaro, Tateishi Keisuke, Yamamoto Keisuke, Yamamoto Shinzo, Asaoka Yoshinari, Ijichi Hideaki, Nagae Genta, Yoshida Haruhiko, Aburatani Hiroyuki, Koike Kazuhiko

Abstract excerpt

Dysregulated DNA methylation followed by abnormal gene expression is an epigenetic hallmark in cancer. DNA methylation is catalyzed by DNA methyltransferases, and the aberrant expression or mutations of DNA methyltransferase genes are found in human neoplasm. The enzymes for demethylating 5-methylcytosine were recently identified, and the biological significance of DNA demethylation is a current focus of...

Topics

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5-Methylcytosine
Cell Transformation, Neoplastic
Cytosine
DNA Methylation
Gene Knockdown Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mixed Function Oxygenases

Proto-Oncogene Proteins

Stomach Neoplasms

Source

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Identifiers

PMID: 22320381
DOI: 10.1111/j.1349-7006.2012.02213.x
PMCID: PMC7659252

Genes

TET1
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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