Article
Loss of TET2 activity limits the ability of vitamin C to activate DNA demethylation in human HAP1 cells
2025-07-02
Abstract excerpt
<h4>ABSTRACT</h4> <h4>Background</h4> The TET family of proteins - TET1, TET2, and TET3 - are α-KG and Fe 2+ dependent dioxygenases that play crucial roles in active DNA demethylation and the deposition of epigenetic marks such as 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxycytosine. TET proteins can also oxidize thymine to 5-hydroxymethyl uracil - a modification whose role is still poorly understoo...
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Identifiers and source
- Literature Corpus work
- bf672c9d-5e87-5165-a074-6f2f0e2541dc
- DOI
- 10.1101/2025.06.27.661936