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Article

Low values of 5-hydroxymethylcytosine (5hmC), the "sixth base," are associated with anaplasia in human brain tumors.

International journal of cancer - 1 Oct 2012

Kraus Theo F J, Globisch Daniel, Wagner Mirko, Eigenbrod Sabina, Widmann David, Münzel Martin, Müller Markus, Pfaffeneder Toni, Hackner Benjamin, Feiden Wolfgang, Schüller Ulrich, Carell Thomas, Kretzschmar Hans A

Abstract excerpt

5-Methylcytosine (5 mC) in genomic DNA has important epigenetic functions in embryonic development and tumor biology. 5-Hydroxymethylcytosine (5 hmC) is generated from 5 mC by the action of the TET (Ten-Eleven-Translocation) enzymes and may be an intermediate to further oxidation and finally demethylation of 5 mC. We have used immunohistochemistry (IHC) and isotope-based liquid chromatography mass spectrometry...

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PMID: 22234893
DOI: 10.1002/ijc.27429

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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