Effects of Alzheimer's disease-associated risk loci on cerebrospinal fluid biomarkers and disease progression: a polygenic risk score approach.

doi:10.3233/JAD-140777

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Article

Effects of Alzheimer's disease-associated risk loci on cerebrospinal fluid biomarkers and disease progression: a polygenic risk score approach.

Journal of Alzheimer's disease : JAD - 1 Jan 2015

Martiskainen Henna, Helisalmi Seppo, Viswanathan Jayashree, Kurki Mitja, Hall Anette, Herukka Sanna-Kaisa, Sarajärvi Timo, Natunen Teemu, Kurkinen Kaisa M A, Huovinen Jaakko, Mäkinen Petra, Laitinen Marjo, Koivisto Anne M, Mattila Kari M, Lehtimäki Terho, Remes Anne M, Leinonen Ville, Haapasalo Annakaisa, Soininen Hilkka, Hiltunen Mikko

Abstract excerpt

BACKGROUND: Several risk loci for Alzheimer's disease (AD) have been identified during recent years in large-scale genome-wide association studies. However, little is known about the mechanisms by which these loci influence AD pathogenesis. OBJECTIVE: To investigate the individual and combined risk effects of the newly identified AD loci. METHODS: Association of 12 AD risk loci with AD and AD-related...

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PMID: 25096612
DOI: 10.3233/JAD-140777

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