Article

Polygenic Risk Score of Sporadic late Onset Alzheimer Disease Reveals a Shared Architecture with the Familial and Early Onset Forms

2017-07-19

Abstract excerpt

<h4>Objective:</h4> To determine whether the genetic architecture of sporadic late-onset Alzheimer’s Disease (sLOAD) has an effect on familial late-onset AD (fLOAD), sporadic early-onset (sEOAD) and autosomal dominant early-onset (eADAD). <h4>Methods:</h4> Polygenic risk scores (PRS) were constructed using previously identified 21 genome-wide significant loci for LOAD risk. <h4>Results:</h4> We found that there...

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Literature Corpus work: 9dbaa631-753a-53f2-9f0b-3aaab8c2dd2a
DOI: 10.1101/165209

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