Article

Connecting genomic and proteomic signatures of amyloid burden in the brain

2024-09-06

Abstract excerpt

<h4>Background</h4> Alzheimer’s disease (AD) has a high heritable component characteristic of complex diseases, yet many of the genetic risk factors remain unknown. We combined genome-wide association studies (GWAS) on amyloid endophenotypes measured in cerebrospinal fluid (CSF) and positron emission tomography (PET) as surrogates of amyloid pathology, which may be helpful to understand the underlying biology of t...

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Literature Corpus work: ac63cfcf-eab2-5564-8858-99819c012187
DOI: 10.1101/2024.09.06.24313124

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