Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Degree of genetic liability for Alzheimer's disease associated with specific proteomic profiles in cerebrospinal fluid.

Neurobiology of aging - 1 Sept 2020

Reus Lianne M, Stringer Sven, Posthuma Danielle, Teunissen Charlotte E, Scheltens Philip, Pijnenburg Yolande A L, Visser Pieter Jelle, Tijms Betty M

Abstract excerpt

Genetic factors play a major role in Alzheimer's disease (AD) pathology, but biological mechanisms through which these factors contribute to AD remain elusive. Using a cerebrospinal fluid (CSF) proteomic approach, we examined associations between polygenic risk scores for AD (PGRS) and CSF proteomic profiles in 250 individuals with normal cognition, mild cognitive impairment, and AD-type dementia from the...

Topics

Join the communities discussing this publication.

alpha-Synuclein
Amyloid beta-Peptides
Amyloid Precursor Protein Secretases
Chitinase-3-Like Protein 1
Cognitive Dysfunction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Peptide Fragments

Source

Identifiers

PMID: 32307133
DOI: 10.1016/j.neurobiolaging.2020.03.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Degree of genetic liability for Alzheimer's disease associated with specific proteomic profiles in cerebrospinal fluid.PMID 32307133Read ↗

A genetic and proteomic comparison of key AD biomarkers across tissuesSemantic proximity Read ↗

Large-scale cerebrospinal fluid proteomic analysis in Alzheimer’s disease patients reveals five molecular subtypes with distinct genetic risk profilesSemantic proximity Read ↗

Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer’s Disease related proteinsSemantic proximity Read ↗

Genetic architecture of plasma Alzheimer disease biomarkersSemantic proximity Read ↗

Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profilesSemantic proximity Read ↗

Effects of Alzheimer's disease-associated risk loci on cerebrospinal fluid biomarkers and disease progression: a polygenic risk score approach.Semantic proximity Read ↗

Pathway-specific polygenic risk scores correlate with clinical status and Alzheimer’s-related biomarkersSemantic proximity Read ↗

Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation.Semantic proximity Read ↗

Proteome-wide association study identifies novel Alzheimer's disease- associated proteinsSemantic proximity Read ↗

Alzheimer's Disease polygenic risk, the plasma proteome, and dementia incidence among UK older adults.Semantic proximity Read ↗

Analysis of Alzheimer’s disease Polygenic Risk Scores using RNA-sequencing provides further novel biological pathwaysSemantic proximity Read ↗

Multi-tissue proteomic signatures of Alzheimer’s disease: a systematic investigation in brain, CSF, blood and an exploratory study in tearsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.