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Article

The PML domain of PML–RARα blocks senescence to promote leukemia

4 Aug 2014

Abstract excerpt

In most acute promyelocytic leukemia (APL) cases, translocons produce a promyelocytic leukemia protein-retinoic acid receptor α (PML-RARα) fusion gene. Although expression of the human PML fusion in mice promotes leukemia, its efficiency is rather low. Unexpectedly, we find that simply replacing the human PML fusion with its mouse counterpart results in a murine PML-RARα (mPR) hybrid protein that is transformed...

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PMID: 25092303
DOI: 10.1073/pnas.1412944111

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