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Article

Two critical hits for promyelocytic leukemia.

Molecular cell - 1 Nov 2000

He L Z, Bhaumik M, Tribioli C, Rego E M, Ivins S, Zelent A, Pandolfi P P

Abstract excerpt

Acute promyelocytic leukemia (APL) is associated with chromosomal translocations that always involve the RARalpha gene, which variably fuses to one of several distinct loci, including PML or PLZF (X genes). Due to the reciprocity of the translocation, X-RARalpha and RARalpha-X fusion proteins coexist in APL blasts. PLZF-RARalpha transgenic mice (TM) develop leukemia that lacks the differentiation block at the...

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Share to Hematopoiesis
Share to Kruppel-Like Transcription Factors
Share to Leukemia, Promyelocytic, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oncogene Proteins, Fusion

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Share to Translocation, Genetic

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Source

Identifiers

PMID: 11106752
DOI: 10.1016/s1097-2765(00)00111-8

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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