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Article

Forced retinoic acid receptor alpha homodimers prime mice for APL-like leukemia.

Cancer cell - 1 Feb 2006

Sternsdorf Thomas, Phan Vernon T, Maunakea Mei Lin, Ocampo Corinne B, Sohal Jastinder, Silletto Angela, Galimi Francesco, Le Beau Michelle M, Evans Ronald M, Kogan Scott C

Abstract excerpt

RARA becomes an acute promyelocytic leukemia (APL) oncogene by fusion with any of five translocation partners. Unlike RARalpha, the fusion proteins homodimerize, which may be central to oncogenic activation. This model was tested by replacing PML with dimerization domains from p50NFkappaB (p50-RARalpha) or the rapamycin-sensitive dimerizing peptide of FKBP12 (F3-RARalpha). The X-RARalpha fusions recapitulated in...

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Share to Leukemia, Promyelocytic, Acute
Share to Myeloid Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oncogene Proteins, Fusion

Share to Protein Structure, Quaternary

Share to Receptors, Cytokine

Share to Receptors, Retinoic Acid

Share to Retinoic Acid Receptor alpha

Share to Retinoid X Receptors

Source

Identifiers

PMID: 16473276
DOI: 10.1016/j.ccr.2005.12.030

Genes

PML
RARA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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