Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PML is required for telomere stability in non-neoplastic human cells

29 Jun 2015

Abstract excerpt

Telomeres interact with numerous proteins, including components of the shelterin complex, whose alteration, similarly to proliferation-induced telomere shortening, initiates cellular senescence. In tumors, telomere length is maintained by Telomerase activity or by the Alternative Lengthening of Telomeres mechanism, whose hallmark is the telomeric localization of the promyelocytic leukemia (PML) protein. Whether...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Retinoids in leukemia and cellular processes
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26119943
DOI: 10.1038/onc.2015.246

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PML is required for telomere stability in non-neoplastic human cellsPMID 26119943Read ↗

The function, regulation and therapeutic implications of the tumor suppressor protein, PMLSemantic proximity Read ↗

PML: Regulation and multifaceted function beyond tumor suppressionSemantic proximity Read ↗

Shelterin complex and associated factors at human telomeresSemantic proximity Read ↗

PML induces compaction, TRF2 depletion and DNA damage signaling at telomeres and promotes their alternative lengtheningSemantic proximity Read ↗

Dynamic PML protein nucleolar associations with persistent DNA damage lesions in response to nucleolar stress and senescence-inducing stimuliSemantic proximity Read ↗

Characterization of Endogenous Human Promyelocytic Leukemia IsoformsSemantic proximity Read ↗

Alternative lengthening of telomeres in mammalian cells.Semantic proximity Read ↗

Functional Connection between Rad51 and PML in Homology-Directed RepairSemantic proximity Read ↗

Regulation of the PML tumor suppressor in drug-induced senescence of human normal and cancer cells by JAK/STAT-mediated signalingSemantic proximity Read ↗

The PML hub: An emerging actor of leukemia therapiesSemantic proximity Read ↗

Telomere Dysfunction in Chronic Lymphocytic LeukemiaSemantic proximity Read ↗

PML bodies provide an important platform for the maintenance of telomeric chromatin integrity in embryonic stem cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.