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Article

Leukemia-associated fusion proteins. Multiple mechanisms of action to drive cell transformation.

Cell cycle (Georgetown, Tex.) - 1 Jan 2005

Insinga Alessandra, Pelicci Pier Giuseppe, Inucci Saverio

Abstract excerpt

Leukemic cells are defined by two main biological features: arrest of differentiation at a specific stage compatible with continued proliferation, and enhanced resistance to stress. Recent work shows that the leukemia-associated fusion protein PML-RAR can mediate both biological effects targeting independent pathways, through a unifying mechanism. Differentiation block is achieved through transcriptional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15611639
DOI: 10.4161/cc.4.1.1400

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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