Article
Retinoic acid receptor fusion proteins: friend or foe.
Molecular and cellular endocrinology - 25 Jul 2000
Breems-de Ridder M C, Löwenberg B, Jansen J H
Abstract excerpt
Acute promyelocytic leukemia (APL) is characterized by a block in differentiation of hematopoietic cells at the promyelocytic stage of development. This disease is uniquely sensitive to treatment with pharmacological doses of all-trans retinoic acid (ATRA), and the combination of ATRA with chemotherapy has improved the durable disease-free survival in these patients to up to 80%. APL is characterized by...
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