Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice

2 Mar 2011

Abstract excerpt

Acute promyelocytic leukemia (APL) is characterized by the t(15;17) translocation that generates the fusion protein promyelocytic leukemia-retinoic acid receptor α (PML-RARA) in nearly all cases. Multiple prior mouse models of APL constitutively express PML-RARA from a variety of non-Pml loci. Typically, all animals develop a myeloproliferative disease, followed by leukemia in a subset of animals after a long...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Protein Degradation and Inhibitors
Share to Retinoids in leukemia and cellular processes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21364283
DOI: 10.1172/jci42953

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in micePMID 21364283Read ↗

Oncogenic K-ras cooperates with PML-RAR to induce an acute promyelocytic leukemia-like diseaseSemantic proximity Read ↗

Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice.Semantic proximity Read ↗

A <i>PMLRAR</i> α transgene initiates murine acute promyelocytic leukemiaSemantic proximity Read ↗

Leukemia initiated by PMLRARalpha: the PML domain plays a critical role while retinoic acid-mediated transactivation is dispensable.Semantic proximity Read ↗

Acute leukemia with promyelocytic features in PML/RARα transgenic miceSemantic proximity Read ↗

A bcr-3 isoform of RARalpha-PML potentiates the development of PML-RARalpha-driven acute promyelocytic leukemia.Semantic proximity Read ↗

PML/RARα and FLT3-ITD induce an APL-like disease in a mouse modelSemantic proximity Read ↗

PML-RAR induces promyelocytic leukemias with high efficiency following retroviral gene transfer into purified murine hematopoietic progenitorsSemantic proximity Read ↗

Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression.Semantic proximity Read ↗

Forced retinoic acid receptor alpha homodimers prime mice for APL-like leukemia.Semantic proximity Read ↗

Transgenic expression of PML/RARalpha impairs myelopoiesis.Semantic proximity Read ↗

Synergy against PML-RARa: targeting transcription, proteolysis, differentiation, and self-renewal in acute promyelocytic leukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.