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Article

A sumoylation site in PML/RARA is essential for leukemic transformation.

Cancer cell - 1 Feb 2005

Zhu Jun, Zhou Jun, Peres Laurent, Riaucoux Florence, Honoré Nicole, Kogan Scott, de Thé Hugues

Abstract excerpt

Pathogenesis of acute promyelocytic leukemia (APL) has been proposed to involve transcriptional repression through enhanced corepressors binding onto RARA moieties of PML/RARA homodimers. Unexpectedly, we show that the K160 sumoylation site in the PML moiety of PML/RARA is required for efficient immortalization/differentiation arrest ex vivo, implying that RARA homodimerization is insufficient to fully...

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Source

Identifiers

PMID: 15710327
DOI: 10.1016/j.ccr.2005.01.005

Genes

PML
RARA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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