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Article

PML/RARα and FLT3-ITD induce an APL-like disease in a mouse model

11 Jun 2002

Abstract excerpt

Acute promyelocytic leukemia (APL) cells invariably express aberrant fusion proteins involving the retinoic acid receptor alpha (RARalpha). The most common fusion partner is promyelocytic leukemia protein (PML), which is fused to RARalpha in the balanced reciprocal chromosomal translocation, t(15;17)(q22:q11). Expression of PML/RARalpha from the cathepsin G promoter in transgenic mice causes a nonfatal...

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PMID: 12060771
DOI: 10.1073/pnas.122233699

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PML/RARα and FLT3-ITD induce an APL-like disease in a mouse modelPMID 12060771Read ↗

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