Article
Association of interleukin 1 receptor-like 1 gene polymorphisms with eosinophilic phenotype in Japanese adults with asthma.
Respiratory investigation - 1 Nov 2017
Inoue Hideki, Ito Isao, Niimi Akio, Matsumoto Hisako, Oguma Tsuyoshi, Tajiri Tomoko, Iwata Toshiyuki, Nagasaki Tadao, Kanemitsu Yoshihiro, Morishima Toshitaka, Hirota Tomomitsu, Tamari Mayumi, Wenzel Sally E, Mishima Michiaki
Abstract excerpt
BACKGROUND: IL1RL1 (ST2) is involved in Th2 inflammation including eosinophil activation. Single nucleotide polymorphisms (SNPs) of the IL1RL1 gene are associated with asthma development and increased peripheral blood eosinophil counts. However, the association between IL1RL1 SNPs and eosinophilic phenotype among adults with asthma remains unexplored. METHODS: In a primary cohort of 110 adult Japanese patients...
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