Article

IL-33 induced gene expression in activated Th2 effector cells is dependent on IL-1RL1 haplotype and disease status

2022-10-21

Abstract excerpt

<h4>Background</h4> IL-33 can activate Th2 cells after binding to the IL-1RL1/IL-1RAcP receptor. However, it is unknown whether disease or genetic make-up regulate IL33 responsiveness of Th2 cells. <h4>Objective</h4> We investigated whether IL-1RL1 asthma risk haplotypes or asthma status influence IL-33-induced Th2 transcriptomic responses in vitro . <h4>Methods</h4> CD4 + T cells from 16 asthma patients an...

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Literature Corpus work: 3032001c-973a-58a9-9739-1237983e0438
DOI: 10.1101/2022.10.20.513024

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