Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling.

doi:10.1172/JCI67119

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling.

The Journal of clinical investigation - 1 Oct 2013

Ho Jennifer E, Chen Wei-Yu, Chen Ming-Huei, Larson Martin G, McCabe Elizabeth L, Cheng Susan, Ghorbani Anahita, Coglianese Erin, Emilsson Valur, Johnson Andrew D, Walter Stefan, Franceschini Nora, O'Donnell Christopher J, Dehghan Abbas, Lu Chen, Levy Daniel, Newton-Cheh Christopher, Lin Honghuang, Felix Janine F, Schreiter Eric R, Vasan Ramachandran S, Januzzi James L, Lee Richard T, Wang Thomas J

Abstract excerpt

The suppression of tumorigenicity 2/IL-33 (ST2/IL-33) pathway has been implicated in several immune and inflammatory diseases. ST2 is produced as 2 isoforms. The membrane-bound isoform (ST2L) induces an immune response when bound to its ligand, IL-33. The other isoform is a soluble protein (sST2) that is thought to be a decoy receptor for IL-33 signaling. Elevated sST2 levels in serum are associated with an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HEK293 Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-1 Receptor-Like 1 Protein

Share to Interleukin-33

Share to Interleukins

Share to Myeloid Differentiation Factor 88

Share to NF-kappa B

Share to Receptors, Cell Surface

Share to Transcription Factor AP-1

Source

Open in PubMed Open full text

Identifiers

PMID: 23999434
DOI: 10.1172/JCI67119
PMCID: PMC3784527

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling.PMID 23999434Read ↗

IL1RL1 asthma risk variants regulate airway type 2 inflammation.Semantic proximity Read ↗

An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s diseaseSemantic proximity Read ↗

IL1RL1 single nucleotide polymorphism predicts sST2 level and mortality in coronary and peripheral artery disease.Semantic proximity Read ↗

Phenotypic and genotypic association of epithelial IL1RL1 to human TH2-like asthma.Semantic proximity Read ↗

Genetic variants in IL-33/ST2 pathway with the susceptibility to hepatocellular carcinoma in a Chinese population.Semantic proximity Read ↗

The central role of IL-33/IL-1RL1 pathway in asthma: From pathogenesis to interventionSemantic proximity Read ↗

Growth stimulation expressed gene 2 (ST2): Clinical research and application in the cardiovascular related diseasesSemantic proximity Read ↗

ST2 and IL-33 polymorphisms and the development of childhood asthma: a prospective birth cohort study in Finnish children.Semantic proximity Read ↗

The role of GATA2 in the expression of the soluble decoy receptor ST2/IL1RL1 in human and mouse mast cellsSemantic proximity Read ↗

Structural and functional consequences of IL33 and IL1RL1 coding variants on IL-33/ST2 signalingSemantic proximity Read ↗

Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium.Semantic proximity Read ↗

ST2 Protein in Heart Disease: From Discovery to Mechanisms and Prognostic ValueSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.