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Article

Feno differentiates epithelial gene expression clusters: Exploratory analysis from the MESOS randomized controlled trial

7 May 2022

Abstract excerpt

Background Understanding how asthma biomarkers relate to gene expression signatures could help identify drivers of pathogenesis. Objective This post hoc exploratory analysis of the phase II tralokinumab trial MESOS (ClinicalTrials.gov identifier NCT02449473) aimed to profile baseline airway inflammation in patients with moderate-to-severe asthma. Methods The T2 and T17 gene expression signatures, 3-gene mean and...

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PMID: 35537502
DOI: 10.1016/j.jaci.2022.04.024

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