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Article

A dynamin mutant defines a superconstricted prefission state.

Cell reports - 7 Aug 2014

Sundborger Anna C, Fang Shunming, Heymann Jürgen A, Ray Pampa, Chappie Joshua S, Hinshaw Jenny E

Abstract excerpt

Dynamin is a 100 kDa GTPase that organizes into helical assemblies at the base of nascent clathrin-coated vesicles. Formation of these oligomers stimulates the intrinsic GTPase activity of dynamin, which is necessary for efficient membrane fission during endocytosis. Recent evidence suggests that the transition state of dynamin's GTP hydrolysis reaction serves as a key determinant of productive fission. Here, we...

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Identifiers

PMID: 25088425
DOI: 10.1016/j.celrep.2014.06.054
PMCID: PMC4142656

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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