"Gearing" up for dynamin-catalyzed membrane fission.

Abstract excerpt

Endocytic dynamins self-assemble into helical scaffolds and utilize energy from GTP hydrolysis to constrict and sever tubular membranous necks of budded endocytic intermediates. They bind the membrane using a pleckstrin-homology domain (PHD). The PHD is characterized by four unstructured loops, two of which partially insert into the membrane. Recent studies reveal that loop insertion lowers the bending rigidity...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Mutation
• Share to Catalysis
• Share to Cell Membrane