Article

Opa1 helical structures give perspective to mitochondrial dysfunction

2022-09-14

Abstract excerpt

Dominant Optic Atrophy is the leading cause of childhood blindness, with 60-80% of cases caused by mutation of the gene encoding the protein Optic Atrophy 1, OPA1. This condition dysregulates the GTPase mediated fusion process of the mitochondrial inner- and outer-membranes. OPA1 is critical to the dynamic organization and regulation of the mitochondria due to its role in cristae remodeling and GTPase-mediated fus...

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Literature Corpus work: e3696b79-bb94-5022-a661-f8614792ba57
DOI: 10.21203/rs.3.rs-2039298/v1

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