Article
Oligomerization of dynamin superfamily proteins in health and disease.
Progress in molecular biology and translational science - 1 Jan 2013
Faelber Katja, Gao Song, Held Martin, Posor York, Haucke Volker, Noé Frank, Daumke Oliver
Abstract excerpt
Proteins of the dynamin superfamily are mechanochemical GTPases, which mediate nucleotide-dependent membrane remodeling events. The founding member dynamin is recruited to the neck of clathrin-coated endocytic vesicles where it oligomerizes into helical filaments. Nucleotide-hydrolysis-induced conformational changes in the oligomer catalyze scission of the vesicle neck. Here, we review recent insights into...
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