Article
Nanoscale dynamics of Dynamin 1 helices reveals squeeze-twist deformation mode critical for membrane fission.
Proceedings of the National Academy of Sciences of the United States of America - 3 Dec 2024
Zhang Yuliang, Lillo Javier Vera, Mohamed Abdelrasoul Mahmoud Shaaban, Wang Yaqing, Arrasate Pedro, Frolov Vadim A, Noy Aleksandr
Abstract excerpt
Dynamin 1 (Dyn1) GTPase, a principal driver of membrane fission during synaptic endocytosis, self-assembles into short mechanoactive helices cleaving the necks of endocytic vesicles. While structural information about Dyn1 helix is abundant, little is known about the nanoscale dynamics of the helical scaffolding at the moment of fission, complicating mechanistic understanding of Dyn1 action. To address the role...
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